Skip to main content

Current Projects

View By:

Cutting-edge research by the best and brightest

Damon Runyon cancer researchers work in technologically advanced labs and leading hospitals across the country.

Select a highlighted state to learn more about the scientists and projects that Damon Runyon is currently funding.

 

Scientists:

 

Alabama

Alaska

Arizona

Arkansas

California

"Identifying cytoplasmic nucleases that shatter micronucleated chromosomes"
"High-throughput precision genome editing for dissecting complex traits in yeast and human cell lines"
"How do tumors evade cell extrusion?"
"Defining the molecular landscape and native interactome of the Siglec-sialoglycan axis in disease"
"Defining how early-life microbial encounters sculpt the B cell repertoire and shape vaccine responses"
"Using commensal skin bacteria for potent, antigen-specific T cell therapy"
"Targeting intrinsic immune signaling in pancreatic cancer with small molecule therapeutics"
"Microbial genome variation in hematopoietic stem-cell transplantation patients"
"Humanize CXCL13 expression in mouse to understand lymphoid neogenesis in cancer"
"Mapping and modeling the human CD4+ T cell differentiation gene regulatory network"
"Mechanisms underlying cis-regulatory rewiring and chromatin reorganization during epithelial to mesenchymal transition"
"Leveraging polyploid Xenopus to probe spindle adaptation to increases in genome size"
"Exploring phase condensation as a general mechanism for organizing cell-cell communication assemblies"
"Mitochondrial ubiquitylation mechanisms to exploit metabolic vulnerabilities in cancer"
"Mechanisms and consequences of microbiota-directed immune responses"
"Regulatory mechanisms of the intestinal microbiome on chimeric antigen receptor T cells"
"Pathogen sensing in fibroblasts restrains antitumor immunity in pancreatic cancer"
"Spatial organization and inheritance regulation of oncogenic extrachromosomal DNA (ecDNA)"
"Characterization of oncogenic kinase signaling by membraneless cytoplasmic protein granules"
"Modulation of neuronal circuitry using sonogenetics"
"Engineered cellular fusogens for novel immune effector functions"
"Inter-organ communication of protein homeostasis stress responses in vertebrate aging"
"Investigating molecular and cellular mechanisms of intra-tumoral heterogeneity in small-cell lung cancer"
"Co-receptors modulating anti-tumor activity of human cytotoxic CD4+ effector cells"
"Targeted genetic supplementation by harnessing transposable elements"
"Smooth muscle cell plasticity in the tumor microenvironment: another parallel between atherosclerosis and cancer"
"Developing a mechanistic multi-scale framework relating signaling and spatiotemporal dynamics in B-cell affinity maturation and lymphomagenesis"
"Drugging K-Ras(G12D) with targeted covalent inhibitors"
"Understanding and engineering combinatorial gene regulation in mammalian cells"
"Spatiotemporal regulation of eDNA release in Pseudomonas aeruginosa biofilms"
"Discovery of novel ligands that treat metabolic disorders"
"Uncovering structural mechanisms of mitochondrial fragmentation in cancer by cellular cryo-electron tomography"
"Characterize the role of non-vesicular cholesterol transport in CD8+ T cell function"
"Constructing one continuous digestive tract, cell by cell"
"Transcription factor cooperation shaping TWIST1 multifunctionality across craniofacial development and cancer metastasis"
"Mechanistic dissection of Tec kinases in immune-cell signaling"
"Sensory innervation of the pancreas"
"Cellular mechanisms linking sleep disturbance and cancer development"
"Molecular mechanisms of heat shock transcription factor 1 in cancer"
"IL13Ra2 Chimeric Antigen Receptor (CAR) T cells for metastatic melanoma"
"Cancer cell-extrinsic and intrinsic control of tumor progression and intratumoral heterogeneity"
"Investigating the dynamics of chromosomal instability in cancer"
"Investigating chemical signaling between gut enteroendocrine cells and intrinsic primary afferent neurons"
"Long-range tumor-host signaling mechanisms driving paraneoplastic syndromes"
"Cell surface mechanisms of neural circuit assembly"
"Spatial regulation of the inheritance of genomic abnormalities in cancer cells"
"Impact of heterogeneity on the cellular recognition of influenza"
"Genetic contributions and novel therapies for individuals with frequent basal cell cancer"
"Understanding and modulating aberrant differentiation in hepatoblastoma" 
"Targeting TGFb pathway dependencies in Group 3 Medulloblastoma" 
"Molecular basis and regulation of apicomplexan parasite motility"
"Calcium signaling and the molecular clock of T cell exhaustion"
"Probing the dynamic organizational network of membraneless organelles through systems-level analysis and imaging"
"Mechanisms of incomplete response and primary resistance to the 3rd generation EGFR inhibitor osimertinib in lung cancer"
"RNA Polymerase II as therapeutic target in AML with RAS activation"
"Identifying functions of regulatory T cell subsets in intestinal inflammation and colorectal cancer"
"Understanding the mechanism of SWI/SNF-mediated chromatin remodeling and its misregulation in cancer"
"Mechanism of dendritic cell missing-self recognition and migration to activate CD4 T cell responses"
"Diagnosis of hematologic malignancies from paucicellular aspirate material using highly multiplexed single cell analysis"
"Mutual repression, bistability, and switch-like decisions during development"
"In vivo characterization of mycobacterial cording"
"Role of ciliary IGF-1/AKT signaling in ciliogenesis, adipogenesis, and tissue regeneration"

"Dissecting the role of pioneer transcription factors in cancer progression"
"Mechanistic characterization of 5’UTR RNA elements that confer translational specificity to shape vertebrate embryonic development"
"Genome editing via an engineered RNA-guided nuclease to create cancer genetic models"
"Molecular mechanisms of guide RNA: target dsDNA binding and PAM recognition by CRISPR-Cas9"
"Sensing lung tumors by pulmonary sensory neurons"
"Identifying the stochastic determinants of drug resistance"
"The therapeutic potential and biological effects of targeting oncogenic KRAS"
"The relationship between epigenetic gene silencing, nuclear architecture, and genome stability"
"Elucidating the AMPK-dependent regulation of mTOR signaling in the metabolic checkpoint of tumorigenesis"
"Interrogating ZAP-70 substrate recognition using high-throughput mutant screening"
"Design of inhibitors of cancer-associated mutant GNAS"
"Probing the relation between sequence, agrregation and proteotoxicity in cardiac amyloidoses caused by free antibody light chains"
"Single-cell analysis and targeting of signaling networks in glioblastoma tumor-initiating cells"
"Longitudinal profiling of host-microbiome interactions in obese patients during drastic weight loss"
"Fate specification of mammary stem cells by cell self-sorting"
"Analysis of CSR- function in C. elegans embryonic cell division"
"Identification of cysteine liabilities in NRF2-driven cancers"
"Identifying metabolic targets of the DNA damage checkpoint"
"Cells, ECM, and the mechanical forces that regulate organ shape"
"How does dynein achieve processivity?"
"Investigating and engineering non-canonical telomere maintenance mechanisms in human cells"
"Regulation of proliferation, migration and angiogenesis by genes uniquely expressed in human neural stem cells"
"Dissecting the mechanism of selective diffusion into the primary cilium"
"Polyphosphates and stationary phase survival"
"Brain tumor suppression by mutation(s) of the voltage-gated sodium channel Para"
"Understanding the role of translational control in humanized mouse models for medulloblastoma"
"Adding a new dimension to flow cytometry: radionuclide-activated cell sorting"
"Reducing cancer susceptibility by attenuating cellular aging"
Dissecting the role of the ciliary transport machinery in oncogenic signal transduction
"Cis-regulatory code for the translational control of gene expression"
"Mechanisms of acquired resistance to Hedgehog pathway inhibitors in basal cell carcinomas"

Colorado

"Chromatin remodeler SMARCAD1 in DNA repair"
"Stress granule regulators and their roles in cancer progression"
"Functional analysis of post-transcriptional RNA regulation in hypoxic macrophages"
"Causes and consequences of rapid cancer cell adaptation to MAPK pathway inhibitors"

Connecticut

"The neuroimmune basis of fatigue"
“Understanding the mechanism of genome packaging in oncogenic herpesviruses"
"From form to function: Cell shape, cell ordering, and gene regulation in bacterial biofilm"
"Understanding RNA splicing in tumor-cell adaptation and anti-tumor immunity"
"Targeting endocrine-exocrine signaling in pancreatic ductal adenocarcinoma progression"
"Elucidating the bacterial determinants of colorectal cancer"
"Evolution of triplex-forming RNAs from random sequences: a search for additional MALAT1-like triplex motifs"
"Mechanistic dissection of the Fanconi anemia pathway in coordinating R-loop processing and DNA repair"

Delaware

Florida

Georgia

"The regulation and function of type IV pili in Acinetobacter biofilm formation"

Hawaii

Idaho

Illinois

"A novel DNA microscopy platform for rapid discovery of immunogenic tumor neoantigens"
“Discovery of chemical probes that support targeted protein degradation in human cancer”
"Development of novel therapeutic strategies for aggressive CTCL subtypes"
"Synthesis and evaluation of a collection of complex molecules biased for penetration of the blood-brain barrier"
"Self-antigen recognition by regulatory T cells"

Indiana

Iowa

Kansas

Kentucky

Louisiana

Maine

Maryland

"Defining microbiome stability and longitudinal shifts as biomarkers of tumor response to immune checkpoint inhibitors across multiple malignancies"
"Endogenous retroviruses modulation of intestinal immune homeostasis and tumor development"
"Mechanisms of centriole number control in multiciliated cells"
"Engineered multispecific antibody-drug conjugates as novel cancer immunotherapeutics"
"In vitro reconstitution of ribosome collision dependent signaling”
"Dual-antigen targeting by ENG-T cells as improved anti-AML therapy"
"Mechanisms of splicing-independent nonsense-mediated mRNA decay"
"Identification and analysis of LncRNAs regulating diffuse large B cell lymphoma"
"Protein crowding and protein folding landscapes as predictors of healthy and diseased cell states"
"Role of chromatin organization in dynamics of transcription initiation"
"Harnessing intra-lymph node controlled release to study and enhance tumor immunity"

Massachusetts

"Probing sensory pathways in gut mechanosensation"
"Discovery and characterization of bacteriophage effectors of bacterial immune systems"
"Engineering novel CAR T cells targeting cancer glycocalyx barrier"
"Elucidating what determines the strength of bacterial transcription terminators"
"Development of haptenizing chimeras for neoantigen generation"
"Predicting leukemia risk from peripheral blood smears"
"Targeting cancer-associated aberrant RNA to treat metastatic melanoma"
"Defining follicular lymphoma transformation: molecular basis, detection and therapeutic vulnerabilities"
"Defining the mechanism of thrombosis in patients with multiple myeloma"
"Uncovering microenvironmental dependencies in follicular lymphoma"
"Signal bottleneck theory for dissecting gene interactions in pancreatic cancer"
"Dissecting the molecular identity and contents of neuronal synapses using spatially resolved RNA sequencing"
"Uncovering signaling mechanisms in somitogenesis through high-throughput genetic screens in robust human organoids"
"Examining bacteria as a source of tumor antigens"
"Identifying the genomic basis for Fusobacterium nucleatum’s colonization of colorectal cancers"
"An integrated imaging- and sequencing-based spatial-omic method to study tumor evolution"
"Epigenetic drivers of resistance to novel therapies for bladder and kidney cancer"
"Elucidating the role of KAT6A and KAT6B in the epigenetic reprogramming of neuroblastoma to enforce neuronal differentiation"
"Defining the mechanistic implications of SF3B1 mutations in MDS"
"Activity-dependent changes in RNA stability as a mechanism for synaptic plasticity"
"Structure and inhibition of the relaxin receptor RXFP1"
"Mechanisms of chromosome fragmentation generating chromothripsis"
"Elucidating PABPC1 sequence preferences and determining how these preferences shape gene regulation"
"Programming next-generation NK cell therapies using targeted protein degradation"
"Tools to target novel cell surface ligands in cancer"
"Understanding the mechanistic basis of gene expression regulation by MLL complexes in cancers"
"Engineering novel CAR T cells for AML: translating lessons from correlative studies and other diseases"
"Characterizing mechanisms of resistance to Menin inhibitors in KMT2A-rearranged and NPM1-mutant AML"
"Charting the tumor antigen landscape of breast cancer"
"The design principles of stable aggregation"
"Molecular and structural basis of gene expression regulation by the nucleosome remodeling and deacetylase (NuRD) complex in human cancer"
"Discovery and characterization of bacterial immunity against RNA phages"
"Estimating growth rates and fluxes using gene expression: Theory and applications"
"Characterization of a novel pathway regulating the protein degradation of immediate-early genes"
"Targeting mitochondrial transporters in cancer"
"X marks the spot: exploring how X-chromosome alterations drive sex differences in cancer"
"Functional dissection of the bacterial-host interface during cell-to-cell spread"
"Understanding how ketone body metabolites influence intestinal stemness, immune responses and tumorigenesis"
"Systematic exploration of the organellar and cellular requirements of pigmentation"
"Elucidating the mechanisms of inflammation in clonal hematopoiesis"
"Using liquid biopsy and MRI to non-invasively identify therapeutic targets for brain metastases"
"Unraveling the role of molecular capacitors that obscure cryptic genetic variants in fish"
"Identifying the selective mechanism behind U2AF1 mutations in lung adenocarcinoma"
"Integration on oncogenic signaling and nutrient sensing by mTOR in tumors"
"Physiology and pathology of the uterus"
"Mitochondrial transporters in metabolite compartmentalization and homeostasis"
"Genome-scale imaging of enhancer-promoter interactions in cancer at single cell resolution"
"Understanding the switch: Competition between chromatin remodeler and polycomb repressive complexes"
"Identifying requirements for lung infection by opportunistic pathogens"
"Deciphering roles of nuclear-mitochondrial communication in cellular homeostasis"
"Developing functional diversity in interoceptive circuits"
"Mechanisms of CD8+ T-cell dysfunction and its therapeutic targeting in T-ALL"
"Targeting telomerase in glioblastoma"
"Inferring cell fate choice from clonal and transcriptomic data, with application to hematopoiesis"
"Mechanism of DNA processing during non-homologous end joining"
"Understanding the physical principles that regulate cell signaling"
"Investigating allosteric mechanisms regulating DNA methyltransferase enzymes"
"Decoding and reprogramming tumor-infiltrating T cells by pMHC-targeted lentiviruses"
"Identification of redox vulnerabilities in genetically defined cancers"
"Dissecting the genetic networks underlying host subversion during Rickettsia infection"
"Dissecting and therapeutically exploiting synthetic lethality between NOTCH and TRIM28 to drive anti-tumor immunity in SCLC"
"Elucidating the mechanisms of cellular evolution with experimental evolution"
"New enzymatic routes towards nitrogen-nitrogen bond formation in diverse cytotoxic natural products"
"Elucidating tissue specificity of cancer"
"Enhancing cancer immunotherapy through epigenetic modulation of the repetitive genome"
"Validating a novel synthetic lethal target for microsatellite unstable cancers"
“Using extreme dose rates to protect healthy tissue in proton radiation therapy”
"Deciphering the Achilles' heel of cancer immunotherapy"
"Role of Lgr6-expressing mesenchymal cells in lung cancer initiation and progression"
"Novel approaches to targeting zinc-finger domain of the transcription repressor BCL11A"
"Predicting the interactions of T cell receptors with peptide-MHC complexes"
"Targeted degradation of the MLL-AF9 fusion oncoprotein in acute myeloid leukemia"
"Epigenetic evolution of pancreatic adenocarcinoma during combination chemotherapy"
"Novel mechanisms for small molecule induced targeted degradation of RRM family proteins"
"Biomolecular condensates in normal and diseased gene regulation"
“Designing signaling proteins to enact anti-tumor responses"
"Inflammatory cell death pathways in Myelodysplastic Syndromes"
"The biology and clinical implications of clonal hematopoiesis in cancer patients"
"Identifying new components of mitochondrial one-carbon metabolism"
"Single-cell genomic approaches for tracing the contribution of inflammation to human colon cancer"
"Exploiting endogenous mutational processes in cancer to enhance response to immunotherapy"
"Characterizing novel molecules and mechanisms that mediate cell-cell communication"
"Decoding Polycomb-mediated gene regulation in single cells with single-molecule super resolution imaging and synthetic biology"
"Developmental mechanisms of killifish cell dispersion and aggregation"
"Mechanisms underlying Fusobacterium nucleatum-driven colorectal cancer"
"Crystal-free crystallography using programmable 3D DNA crystal frameworks"
"Cell sorting in zebrafish neural tube development"
"Investigating the role of aneuploidy and haploinsufficiency in driving tumorigenesis"
"Mechanisms of xenobiotic surveillance and regulation"
"Understanding the mechanism and roles of changes in chromatin composition in the brain"
"Elucidating the mechanism of chromosome bridge resolution"
"Mechanism and regulation of primary-microRNA processing"
"Replicative helicase bypass of bulky DNA adducts?"
"Examining the biological function of 5-hmC modification in the mammalian genome"
"Elucidating the mechanism of CHD5-mediated tumor suppression in neuroblastoma"
"Molecular and cellular characterization of a novel LincRNA in neuroblastoma"
"The role of DOT1L in pediatric leukemias"
"Targeting the EWS-FLI oncoprotein in Ewing sarcoma with CDK12/13 inhibitors"
"Determining the role of aberrant growth factor signaling in maintaining disease-propagating cells and mediating JAK2 inhibitor resistance in myeloproliferative neoplasms"
"Mechanisms of disease and resistance in CRLF2-rearranged B-cell acute lymphoblastic leukemia"

Michigan

"Therapeutic opportunities and biological mechanisms for protein-RNA dyssynchrony in medulloblastoma"
"Understanding CD8 T cell epigenetic changes fueled by S-adenosylmethionine metabolism for improved adoptive cell therapy"
"Targeting metabolic interactions in the glioblastoma microenvironment to overcome therapy resistance"
"Targeting TRIM29 to reverse immune checkpoint inhibitor resistance in bladder cancer"
"Investigating the mechanism of retro-translocation by ERAD"
"Single-molecule analysis of telomerase recruitment to telomeres"
"Neural and genetic basis of metabolic regulation"

Minnesota

"Antigen-independent proliferation of tissue-resident memory T cells and therapeutic applications"
"Single-molecule dynamics of DNA repair assemblies in live cells"

Mississippi

Missouri

"COPS5 as a novel therapeutic target in platinum-resistant ovarian cancer"
"Tailored cellular engineering to overcome costimulation-driven CAR T cell dysfunction"
"The use of ivosidenib in IDH1-mutated clonal cytopenia of undetermined significance"
"Characterizing the immunogenic landscapes of malignant brain tumors"
"Defining a targetable oncogenic dyad in bladder cancer"
"Leveraging NFkB pathway dysregulation for therapeutic benefit in myeloproliferative neoplasms"

Montana

Nebraska

Nevada

New Hampshire

"tRNA dysregulation and cancer"

New Jersey

"Chemoproteomic platforms for deciphering and drugging redox regulation between methionine and methionine sulfoxide in pancreatic cancer"
"The biophysics of substrate recognition in chromatin remodeling"
"Developing tools to decode endogenous protein monoaminylation"
"Screening migratory modes and drug delivery schedules in 3D spheroids of triple-negative breast cancer cells"
"Investigating bacterial small RNA-mediated regulation of host behavior"
"Defining quorum-sensing signaling patterns and their effects on gene expression and morphology in V. cholerae biofilms at the single-cell and community levels"
"Modeling spatial organization and interactions among genetic and epigenetic states across cancer types"
"Contact tracing within an organism: developing a genome editing platform to record the history of virus-infected and transformed cells"
"Sculpting chromatin architecture in live cells using protein chemistry"
"Molecular and cellular regulators of blood-brain barrier function"

New Mexico

"Chemoproteomic platforms for deciphering and drugging redox regulation between methionine and methionine sulfoxide in pancreatic cancer"
"Identifying cytoplasmic nucleases that shatter micronucleated chromosomes"
"High-throughput precision genome editing for dissecting complex traits in yeast and human cell lines"
"Neuroimmune: cancer stem cell interactions in the tumor microenvironment"
"How do tumors evade cell extrusion?"

New York

"Neuroimmune: cancer stem cell interactions in the tumor microenvironment"
"Dissecting heterogeneous cellular responses to oncogenic KRAS inhibition in pancreatic adenocarcinoma"
"Immunologic targeting of 'undruggable' TP53 hotspot mutations through T cell receptor gene therapy"
"Origin and evolution of long-lived CAR T cells in patients with hematologic malignancies"
"A probabilistic framework for deconvolving causal mechanisms of cancer therapeutics with genetic perturbation screens"
"A new platform to study cancer biology and therapy in humans"
"Overcoming metabolic suppression of anti-tumor immunity in gastric cancer"
"Dissecting spatial crosstalk in squamous cell carcinoma arising in organ transplant recipients"
"Understanding the role of KMT2D in MLL-AF9 acute myeloid leukemia"
"Emergency myelopoiesis pathways as common drivers of clonal dominance and disease progression in acute myeloid leukemia"
"The gut-brain axis mediating overnutrition"
"Untangling the evolutionary dependency of childhood leukemia"
"Epigenetic coupling of DNA methylation and chromatin structure on leukemic transformation and therapeutic response"
"Molecular mechanisms of human APOE-mediated myeloid cell modulation in cancer"
"Physics-driven prediction of drug-resistant clinical mutations to improve precision oncology"
“Molecular recording of tumor evolution in response to macrophage modulations”
"Investigating and targeting T cell exhaustion in solid tumors"
"Investigating and targeting T cell exhaustion in solid tumors"
"Decode the senescent cell surface in vivo and develop cell therapies for senescence-related diseases"
"An atlas of fibroblast cell states in health and disease through functional genomics"
"Investigating the role of fitness and host pressure in shaping hepatitis B diversity"
"Statistical modeling of cell-cell interactions in normal intestine, inflammatory bowel disease and colorectal cancer using single cell and spatial transcriptomics"
"Targeting cancer nutrient limitations using dietary interventions"
"A spatially patterned stem cell and immune cell barrier at the skin surface"
"Elucidating how pDC genome organization regulates IFN production in cancer"
"In situ single-cell dissection of the tumor-microenvironment interplay mediating brain metastasis"
"Leveraging multi-modal genome profiling approaches to study disease initiation, progression, and response to therapy in TP53 mutated myeloid neoplasms"
"Tracing molecular oxygen in pancreatic cancer"
"The studies of double-strand break proteins in germline genome transmission"
"Leveraging patient-derived organoid models to define the molecular determinants of metastatic regeneration"
"Mechanisms of radiation tolerance in Caenorhabditis from Chernobyl"
"Dynamics and consequences of complex karyotype evolution in p53 driven acute myeloid leukemia"
"Determining the distal effects of gut microbiota on the lung tumor microenvironment, cancer progression, and checkpoint blockade efficacy"
"Interrogating functional contribution of JAK2V617F in the maintenance of myeloproliferative neoplasms"
"Clinical development of next-generation T cell receptor (TCR)-based adoptive immunotherapies for the treatment of patients with common epithelial malignancies"
"Metabolic coupling of the hypoxic niche to stemness"
“Codon- and nutrient-specific regulation of mRNA translation in pancreatic cancer”
"Seeking and evaluating novel therapeutic targets in human lung adenocarcinomas with loss-of-function mutations in LKB1"
"Immune-epidermal stem cell crosstalk in skin inflammation"
"Chromatin dysregulation as driver of oncogenesis"
"Overcoming resistance to anti-PD1 immunotherapy in hepatocellular carcinoma"
"Precision T cell receptor-based cancer therapies"
"Modeling responses to targeted ERK signaling inhibition at the single-cell level"
"Recombinant interleukin-33 immunotherapy for pancreatic cancer"
"High-resolution studies of dynein structure and mechanism"
"Targeting allosteric control in the Ras-MAPK pathway for cancer therapy"
"Cell cycle regulation of cellular behaviors associated with cancer metastasis"
"Cell cycle regulation of cellular behaviors associated with cancer metastasis"
"Use of mobile applications to evaluate post surgical recovery in aging patients with GI cancer"
"Subtype-specific modes of clinical and molecular progression in prostate cancer"
"Using 'single-cell genomics' to resolve the molecular identity of 'cancer stem cells,' and guide their pharmacological eradication"
"Identifying determinants of latency in brain metastatic breast cancer cells"
"Structure and mechanism of the voltage-gated potassium channel hEag1"
"The role of tension in Hippo pathway signaling"
"Investigation of potential roles of serum amyloid A in peripheral Th17 cell pathogenicity"
"AMPK-induced catabolism of extracellular proteins: a novel survival mechanism for nutrient-deprived cancer cells"
"Mechanisms of directed cell migration in a complex in vivo environment"
"Uncovering the role of RNA-binding protein Syncrip in acute myeloid leukemia (AML)"
"Genomic assessment of de novo germline cancer susceptibility in pediatric malignancies"
"Understanding and targeting altered histone modifiers in the myeloid malignancies"
"Genetic dissection of pediatric classic Kaposi sarcoma"
"Utilizing genome sequencing to elucidate mechanisms of resistance in advanced prostate cancer"

North Carolina

"Mechanisms of microbial modulation of cancer immunotherapy"
"Investigating the role of EMT-mediated dendritic cell tolerization in checkpoint inhibitor resistance"
"Personalized prebiotics to optimize microbiota metabolism and improve transplant outcomes"
"Personalized prebiotics to optimize microbiota metabolism and improve transplant outcomes"

North Dakota

Ohio

"Harnessing clinical data to identify new prostate cancer therapeutics"
"Maximizing pro-apoptotic protein levels"

Oklahoma

Oregon

"Whole-cell modeling for the prediction and control of micro-environmentally regulated proliferative and migratory variability"

Pennsylvania

"Investigating chromatin architectural dynamics mediated by LDB1 in T-cell acute lymphoblastic leukemia"
"Understanding and targeting chromatin reorganization in ATRX deficient sarcomas"
"Harnessing the immune response to cancer through the microbiota"
"Hepatic urea cycle function in NASH-induced HCC progression"
"How do eukaryotic cells count cell cycles? Intrinsic regulation of quantized asexual replication cycles and commitment to sexual differentiation in the protozoan parasite Cryptosporidium parvum"
"Y chromosome proteins in sex bias of cancers in non-reproductive organs"
"Investigation of the role of peripheral secreted molecules on sleep and circadian rhythms"
"Investigating neuro-immune interaction in lung cancer"
"Illuminating error correction strategies in early development"
"Shared antigen and neoantigen-specific T cells in checkpoint blockade efficacy and toxicity"
"Evaluating and targeting pathways of treatment resistance in head and neck squamous cell carcinoma"
"Metabolic determinants of codon usage bias in colorectal cancer"
"Epigenetic and genetic mechanisms of cancer in Beckwith-Wiedemann Syndrome"
"Master microbial manipulators: how hosts are shaped by bacterial interactions"
"Defining the role of epigenetic enhancer dysfunction in epithelial carcinogenesis"
"Bacterial cell fates: The role of quorum sensing in biofilm patterning"
"GPC2 as an oncogene and immunotherapeutic target in high-risk neuroblastoma"

Rhode Island

South Carolina

South Dakota

Tennessee

"Targeting Clostridioides difficile biofilm dynamics to combat recurrent infections"
"Targeting the developmental architecture of rhabdomyosarcoma"
"Defining endothelial progenitor cell pliancy in rhabdomyosarcoma" 
"Investigation of CITED2 as a novel dependency in Ewing sarcoma"

Texas

"Immune evasive circuits that define MRD progression in myelodysplastic syndrome"
"Structure- and lineage-based classification and targeting of resistance in EGFR-mutant NSCLC"
"Multi-modality approach to enhancing antigen presentation in breast cancers"
"Immunologic responses to short course radiotherapy in rectal adenocarcinoma and the impact of CD40 agonist immunotherapy"
"Identifying metabolic vulnerabilities in Hürthle cell carcinoma"
“Investigation of Hedgehog and Wnt signaling mechanisms”
"Regulation of integrin clustering on supported lipid bilayers"
"Using chemistry to identify new targets in lung cancer"

Utah

"Protein evolution at the host-virus interface"
"Targeting phosphatidylcholine metabolism in liver cancer using zebrafish"
"Targeting phosphatidylcholine metabolism in liver cancer using zebrafish"
"Novel roles for retrogenes in host immunity"

Vermont

"EBUS-TBNI of cisplatin optimization in heterogeneous lung tumors"

Virginia

"Single-molecule imaging of transcription factors binding dynamics in Drosophila embryos"

Washington

"Decoding the transcription code: de novo protein design for precise gene regulation"
"A computational platform for predicting whole-embryo morphologies from single-cell transcriptomes"
"Investigating innate immune activation in the autoimmune pancreas"
"Quantitative analysis to elucidate spatial-temporal heterogeneity of therapeutic T cell dysfunction mechanisms in the context of adoptive cell therapy against pancreatic cancer"
"Deciphering clonal competition between oncogenic mutant and normal cells and its effect on cancer initiation"
"Genetic conflicts shape protamine evolution"
"At-scale dissection of developmental enhancers with single-cell reporters"
"Precision therapeutics for hematologic malignancies with splicing factor mutations"
"Quantifying a polyclonal immune repertoire's ability to bind influenza"
“Fundamental mechanisms that underlie human translation initiation and its dysregulation in cancer”
"Initiation of type 2 immune responses"
"Mapping paths and mechanisms of virus-host adaptation"
"Global analysis of DNA break repair by single-cell sequencing"
"Impact of heterogeneity on the cellular recognition of influenza infection"
"Evolutionary and functional consequences of genetic conflicts between KRAB-Zinc-Fingers and endogenous retroviruses in primate genomes"
"Participatory genetics for defining genotype-phenotype associations of rare cancer variants"
"Segregating the GVL effect from GVHD in humans"
"The impact of the colonic microbiota on reconstitution of CD161hi cells and clinical outcomes after allogeneic hematopoietic stem cell transplantation"

West Virginia

Wisconsin

Wyoming