Dr. Soh focuses on how viruses such as influenza evolve to infect diverse host species. Zoonotic transmissions of influenza from avian and swine hosts to humans have the potential to result in pandemics with severe public health consequences. Cancer patients, in particular, are disproportionately susceptible to complications arising from infection. Dissecting the pathways and mechanisms by which influenza can adapt to the human host will aid in the ability to predict and prevent pandemics resulting from zoonotic infection.