Dr. Mann is investigating why the “killer” T cells of our immune system gradually lose the ability to recognize and kill cancer cells. Immunotherapy aims to revitalize these dysfunctional “exhausted” T cells, but a better understanding of how T cells recognize markers on cancer cells called antigens is needed. Dr. Mann is testing the response of engineered T cells to antigen stimulation at different durations, frequencies, and intensities. These studies will focus on understanding the role of calcium signaling in the failure of T cell response. Unraveling the molecular mechanism of T cell exhaustion may help in the design of therapies to prevent or alter its progression, potentially leading to improved immunotherapies.