Ash Alizadeh (Damon Runyon Clinical Investigator ’14-’17) and colleagues at Stanford University School of Medicine reported that circulating tumor DNA (ctDNA) profiling by non-invasive liquid biopsy reveals distinct patterns of clonal evolution and allows accurate classification of tumor subtypes in lymphoma patients. This enables insights into the biology of how an indolent disease transitions into an aggressive and often fatal disease. The analysis enables identification of previously undescribed factors underlying lymphoma clinical outcomes and could facilitate individualized therapy for patients. The report was published in the journal Science Translational Medicine.