Oren J. Becher, MD (Damon Runyon Clinical Investigator ’12-’15) of Duke University, Durham, Laura A. Banaszynski, PhD (Angelo Family Fellow ‘08-‘11) of The Rockefeller University, New York, and colleagues, reported results that, for the first time, link a mutated histone protein to a rare brain stem cancer in children called diffuse intrinsic pontine gliomas (DIPG). This histone typically silences expression of certain genes; when the histone is mutated in DIPG, cancer-promoting genes are aberrantly turned on. This study was published in the journal Science.