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Peripheral T-cell lymphoma genome sequenced

Andrew L. Feldman, MD (Damon Runyon Clinical Investigator ‘09-‘14), and colleagues at Mayo Clinic, Rochester, reported the completion of the world’s first genome-wide sequencing analysis of peripheral T-cell lymphomas, a highly aggressive cancer of the immune system. The team found 13 genetic abnormalities, five of which involve genes related to the tumor suppressor p53. These findings will ultimately be used to improve diagnostic tests and develop targeted treatments for this type of lymphoma. The study was published in the journal Blood