Andrew T. Chan, MD, MPH (Damon Runyon Clinical Investigator ‘08-‘13) of Massachusetts General Hospital, Boston, and colleagues, reported that the association between aspirin use and risk of colorectal cancer was affected by mutation of the gene BRAF. Researchers found that regular aspirin use was associated with a lower risk of BRAF-wild-type colorectal cancer but not with risk of BRAF-mutated cancer. These results were published in the journal JAMA.