Scott A. Armstrong, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘03-‘08) of Dana-Farber Cancer Institute and Children’s Hospital Boston, and Kornelia Polyak, MD, PhD (Clinical Investigator Award Committee Member) of Dana-Farber Cancer Institute, Boston, are two of this year’s recipients of the Paul Marks Prize for Cancer Research. The awards recognize three young investigators under the age of forty-six for their exceptionally innovative work that has helped to advance the field of cancer research. Dr. Armstrong is recognized for notable achievements in the fields of cancer stem cell research and genomics that have led to landmark findings pointing to potential new therapies for leukemia. Dr. Polyak is recognized for her pioneering genomic discoveries in normal and cancerous breast tissue and for her efforts to translate those findings into improved diagnostic and therapeutic approaches.